March 27, 2023 – Excellent news and dangerous information on the lengthy COVID entrance: Sure teams of individuals – like ladies, people who smoke, and people who had extreme COVID-19 infections – are at a better threat of lengthy COVID, a assessment of greater than 800,000 sufferers has discovered. 

That’s the dangerous information. But, researchers additionally discovered that sufferers who had at the least two doses of the COVID vaccine had a considerably decrease threat of getting lengthy COVID down the road. 

“Not solely is it vital to acknowledge which people could also be at excessive threat of growing PCC [post−COVID-19 condition] and to supply follow-up care; it’s crucial to plan population-level public well being measures,” wrote lead creator Vassilios Vassiliou, PhD, a professor of cardiac medication on the College of East Anglia in Norwich, England, and his crew. 

The analysis, printed within the journal JAMA Inside Drugs, mixed 41 beforehand printed articles that included data from 860,783 sufferers. The assessment uncovered a slew of demographic traits that had been considerably linked to lengthy COVID, together with feminine intercourse, being over 40 years previous, smoking, having a excessive physique mass index (BMI), and hospitalization because of a COVID-19 an infection. 

Lengthy COVID, as outlined by the World Well being Group, is the continuation of COVID signs or the beginning of latest signs at the least 3 months after preliminary an infection.

Having different circumstances – like anxiousness, melancholy, bronchial asthma, diabetes, and being immunocompromised – had been additionally linked to a better chance of getting lengthy COVID, researchers reported. 

That cisgender ladies are at a better threat of lengthy COVID falls according to earlier analyses, suggesting that hormones may play a task “in perpetuating the hyperinflammatory standing of the acute section of COVID-19 even after restoration.” 

The identical goes for earlier research on vaccination standing and lengthy COVID threat – like a lot of the earlier analysis on the topic, vaccinations had been discovered to have a protecting impact on lengthy COVID. 

However lengthy COVID – all of the methods it presents itself, how widespread it’s, and what we are able to do about it – nonetheless stays considerably of a thriller, even 3 years into the pandemic. 

“Whereas this and different information on vaccines recommend that there are components that may cut back the danger of lengthy COVID, nothing as of but can fully eradicate the danger of lengthy COVID. The one assure towards lengthy COVID is to not get COVID,” mentioned Stanford College major care professor Linda Geng, MD, PhD. 


“Moreover, we nonetheless shouldn’t have any efficient remedy established for the tens of millions who have already got lengthy COVID, and we urgently want randomized managed trials to assist present these solutions,” she mentioned.

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