By Denise Mann 

HealthDay Reporter


TUESDAY, March 28, 2023 (HealthDay Information) — When you’re one of many thousands and thousands of individuals with allergic bronchial asthma or eczema, it’s possible you’ll be extra more likely to develop the wear-and-tear type of arthritis as you age.

That is the primary discovering from a brand new research that examined the chance of growing osteoarthritis amongst folks with the 2 allergic situations.

The research wasn’t designed to say how, or even when, these allergic ailments enhance osteoarthritis danger, however the researchers do have a principle.

“Our group has completed work displaying that mast cells [a type of allergic cell] are elevated in numbers within the joints of individuals with osteoarthritis, and their exercise contributes to the event of osteoarthritis,” mentioned research writer Dr. Matthew Baker, medical chief within the division of immunology and rheumatology at Stanford College in Stanford, Calif.

And bronchial asthma and eczema will be the tip of the iceberg, he mentioned.

“It’s potential that different atopic situations similar to seasonal allergic reactions, meals allergic reactions and/or allergic rhinitis [hay fever] might present the same danger,” Baker famous.

These researchers didn’t have a look at these situations within the new research.

For the research, they reviewed insurance coverage claims from two databases. The primary set included greater than 117,000 folks with bronchial asthma or eczema and 1.2 million folks with out these situations. After eight years of follow-up, the chance of growing osteoarthritis was 58% greater amongst people with allergic bronchial asthma or eczema than amongst their counterparts with out these allergic situations.

The chance of osteoarthritis was even greater amongst individuals who had each allergic bronchial asthma and eczema, the research findings confirmed.

About half of individuals with eczema even have allergic situations similar to hay fever, bronchial asthma or meals allergic reactions, in accordance with the American Academy of Allergy, Bronchial asthma and Immunology.

The researchers additionally in contrast the chance of growing osteoarthritis amongst folks with allergic bronchial asthma to these with persistent obstructive pulmonary illness (COPD), a lung illness that doesn’t contain allergic pathways. Folks with bronchial asthma have been 83% extra more likely to develop osteoarthritis than these with COPD.

Within the second database, the chances of growing osteoarthritis have been 42% greater amongst folks with both allergic bronchial asthma or eczema and 19% greater amongst these with each situations. These findings weren’t as strong as these seen within the first set as they took physique mass index (BMI) under consideration. (BMI is a estimate of physique fats based mostly on peak and weight.) A excessive BMI is a danger for growing osteoarthritis.

The million-dollar query is whether or not treating bronchial asthma or eczema lowers arthritis danger. The researchers did not have a look at this on this research, however there may be motive for hope.

Older analysis has linked the usage of antihistamines with decreased structural development in knee osteoarthritis, Baker mentioned.

“We’re hopeful that any variety of medication that work to inhibit mast cells or mast cell merchandise [such as histamine] will cut back the incidence of osteoarthritis,” he mentioned.

The research — revealed March 27 within the Annals of the Rheumatic Ailments — was funded by the U.S. Nationwide Institutes of Well being.

The connection between osteoarthritis and allergic ailments might be the low-grade irritation, mentioned Dr. Theodore Fields, a rheumatologist on the Hospital for Particular Surgical procedure in New York Metropolis, who reviewed the findings.

The excellent news is that there are extra therapies for eczema as we speak than ever earlier than and lots of extra are within the pipeline.

“If remedy of atopic illness helps forestall or reduce osteoarthritis, there are a whole lot of choices and will likely be extra,” Fields mentioned.

“For sufferers with eczema or bronchial asthma, this information could make them conscious that they could be extra more likely to get osteoarthritis,” he mentioned.

When you have an allergic illness and develop aches and pains in your joints, see your physician, he suggested.

“We now have many methods to enhance the signs of osteoarthritis however do not but have a disease-modifying remedy,” Fields mentioned.

“There could be some hope on this research for sufferers with eczema or bronchial asthma that their remedy for atopic illness may forestall or diminish their potential to develop osteoarthritis,” he added.

Extra info

The American Academy of Allergy, Bronchial asthma & Immunology has extra on eczema.



SOURCES: Matthew Baker, MD, medical chief, division of immunology and rheumatology, Stanford College, Stanford, Calif.; Theodore Fields, MD, rheumatologist, Hospital for Particular Surgical procedure, New York Metropolis; Annals of the Rheumatic Ailments, March 27, 2023

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